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As part of a corporate restructuring, the business operations of Dorner GmbH & Co. KG were transferred as of December 31, 2025, to the former general partner, Dorner Verwaltungs GmbH. As part of this process, the company was renamed Dorner Health IT Solutions GmbH (registered in the Commercial Register of the Freiburg i. Br. Local Court under HRB 300542). With this step, we are aligning our corporate structure within … Read more

Digital Workflows in Pathology

Pathology at the Limit—Is There More to Come?

Paper forms, media discontinuities, missing contextual information—this is still how the diagnostic process begins in many pathology departments. For pathologists, this means asking questions, searching, and waiting. At best, it results in a loss of time; at worst, diagnostic uncertainty.

This is exactly where the BMBF-funded HORUS project comes in: Virtual histology using micro-CT is set to become a reality in clinical practice—integrated into real-world workflows, supported by AI and digital process integration.

The DORNER Article – Experience Meets Innovation

For new technologies to be effective, a stable foundation is needed. This is where DORNER brings its more than 20 years of experience with the Workflow Engine to bear. This flexible web framework has been mapping complex medical processes for years—in projects such as ravenna and isendi, as well as now in HORUS.

The result: a system that not only transmits data but also intelligently controls processes.

Step 1: Order Creation – Digital, Structured, Context-Rich

A new case is being admitted to the clinic. Instead of handwritten forms, all data is entered digitally:

  • Structured requirement data instead of free text
  • Graphical location labels on organ diagrams (liver, lungs, etc.)
  • Automatic Translation into Codes (SNOMED, LOINC)
  • Previous findings, lab results, and AI-based summaries of doctors' notes are visible directly within the order
  • Validation checks prevent missing information

👉 For pathologists, this means that all information is available in its entirety and in context right from the start.

Digital Process Support - Graphical Location Information - Organ Diagrams

Step 2: Order Transfer – Say Goodbye to Media Breaks

In the lab, the system handles the organization:

  • The Order Monitor displays the status of all cases
  • Samples are recorded by scanning a barcode
  • Import all order data, including attachments —without any media breaks
  • Automatic Assignment to a Processor
  • Feedback on Micro-CT utilization directly within the system

👉 Result: Transparency from the very beginning.

Step 3: Order Processing – AI and Micro-CT in the Workflow

Now the diagnostic process begins. And this is where it becomes clear why digital workflows in pathology are more than just an IT gimmick:

  • Micro-CT: Not available in real time → therefore, clear process integration with status updates and runtime data
  • Interfaces enable:
    • Order with all relevant data
    • Structured Import of Findings
    • Integration of the ImFusion Viewer for Image Analysis
  • Semi-automated report generation assists pathologists with structured input forms and standard text templates
  • AI-powered analyses complement traditional histology

👉 Pathologists work consistently within the same system—without any gaps or loss of information.

Step 4: Display of Findings and Feedback – Immediately Available at the Hospital

The diagnostic findings are also fed back just as smoothly:

  • Digital Display of Findings for All Parties Involved
  • Monitoring functions, such as for surgery appointments
  • Structured Transmission of Medical Findings to the HIS
  • Automatic coding (ICD, TNM, etc.) and transfer of diagnoses, scores, and performance data

👉 This means that the findings are not only documented but can also be put to immediate clinical use.

Conclusion: When Digitalization Really Helps

HORUS makes it clear: Workflow is more than just data routing. It’s about process intelligence —that is, what pathologists need, when they need it, in what form, and with what level of contextual detail.

With its Workflow Engine, DORNER provides a platform that seamlessly and intelligently integrates micro-CT, AI, and traditional histology.
The result: fewer follow-up questions, greater certainty, and better diagnostics.

Want to learn more?

Learn more about the HORUS project and our workflow solutions —or contact us directly. We look forward to hearing from you!

HORUS research project

Every year, around 500,000 people in Germany are diagnosed with cancer. Pathologists have a central responsibility in diagnostics: they analyze almost 40 million tissue samples every year, usually on the basis of a few histological sections selected on the basis of experience.

However, this traditional process has its limits - relevant structures remain hidden in the often extensive FFPE (formalin-fixed, paraffin-embedded) tissue blocks. This is precisely where the BMBF-funded research project HORUS (13GW0571D) comes in.

In our new project video, we provide insights into:

  • The perspectives of the researchers involved

  • The innovative imaging and analysis workflow

  • The future of AI-assisted cancer diagnostics and virtual histology

Virtual histology with micro-CT: How HORUS is rethinking cancer diagnostics

What does "virtual histology with micro-CT" mean?

The aim of virtual histology is to examine tissue samples three-dimensionally and non-destructively before they are cut microscopically. At the heart of this is micro-CT imaging - a high-resolution X-ray technique that uses phase contrast and absorption CT to visualize structures ranging from 10 µm fine capillaries to millimetre-sized germinal centers.

In combination with artificial intelligence (AI) and annotation tools, critical areas such as tumor margins, blood vessels or germinal centers can be precisely marked and analyzed. Pathology laboratories can thus specifically identify the relevant part of a tissue block before it is further processed under the microtome.

Why is this a breakthrough for pathology?

  • Significantly higher precision:
    Thanks to the combination of virtual histology and micro-CT, the sampling error can be reduced by a factor of 1,000 to 5,000.
    While current diagnoses are often based on just a few 2-micrometer sections, HORUS makes it possible to analyze the entire tumor volume - from centimeter-sized tumors to fine 10-25 µm structures such as capillaries or glands.

  • Gentle diagnostics:
    The FFPE tissue block is completely preserved so that it can continue to be used for molecular genetic analyses. Pathologists no longer have to decide which part of the sample should be sacrificed.

  • More efficient workflows:
    The 3D preview and AI-supported annotation allow relevant areas to be specifically identified, which will optimize working time in the future without additional effort - a decisive advantage in view of the shortage of specialist pathologists in Germany.

  • Digital networking:
    With the help of the software used, such as the ImFusion Suite, micro-CT data and conventional histology can be merged in a digital workflow that can be integrated into existing laboratory processes in the future.

Digital infrastructure: Our HORUS contribution

For virtual histology to work not only technologically, but also in everyday clinical practice, smooth processes are needed in the background.
In the HORUS project, we have incorporated our tried-and-tested workflow engine - which can be used to reliably map medical processes from digital order entry and AI-supported context data to structured reporting of findings.
A special feature: the graphic marking of the sampling site by the clinic user - automatically coded and clearly visible to pathologists.

The HORUS project partners

The HORUS project (funding reference 13GW0571D), funded by the German Federal Ministry of Education and Research (BMBF), brings together research, clinical practice and industry. The partners are pooling their expertise to bring virtual histology with micro-CT into practice.

Federal Ministry of Education and Research (BMBF)
Funds the project within the framework of medical technology to support innovative diagnostic procedures and enable their transfer to clinical application.

University Hospital Düsseldorf - Institute of Pathology
Provides clinical expertise and patient samples and tests the developed methods directly in cancer diagnostics, especially in the field of tumor characterization and tissue analysis.

Freiburg University Medical Center - Institute of Pathology
Works on the integration of micro-CT data into the pathological workflow and ensures that the methods meet clinical requirements.

ImFusion GmbH
Develops AI-supported software solutions for image fusion, segmentation and annotation so that pathologists can combine micro-CT and histology in a digital workflow.

Fraunhofer Institute for High-Speed Dynamics, EMI
Advances the technical development of micro-CT imaging and optimizes the preparation of tissue samples for phase-contrast-based imaging.

DORNER Health IT Solutions
provides support with technological expertise and data management so that the developed processes can be implemented in a scalable and practical manner.

Conclusion

HORUS is a pioneering approach to cancer diagnostics:
Virtual histology with micro-CT and artificial intelligence make it possible to see more, destroy less and diagnose faster - with maximum precision.

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