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The world of laboratory diagnostics and biomedical research is undergoing a revolution through the use of advanced technologies such as laboratory information and management systems (LIMS). A notable example of this development is the introduction of the DORNER Genetics LIMS at LabDia Labordiagnostik and the St. Anna Children's Cancer Research Institute in Vienna. 

This blog post highlights how St. Anna Children's Cancer Research Institute (CCRI) and LabDia Laboratory Diagnostics have revolutionized their work processes by integrating an advanced LIMS.

Integration and efficiency with DORNER Genetics LIMS

The main goal of LabDia LaborDiagnostik is to create a comprehensive system that brings together the various specialist departments - including hematology, oncology, infectiology, human genetics and immunology. The DORNER Genetics LIMS enables them to efficiently manage sample tracking, shared reporting and access to results from other departments.

Challenges and solutions at the St. Anna Children's Cancer Research Institute

The St. Anna Children's Cancer Research Institute, known for its groundbreaking research in pediatric oncology, faces the challenge of coordinating different laboratory processes. The research spans various specialties, with each area placing specific demands on the LIMS. The diversity of methods such as NGS, Sanger sequencing, FACS, MLPA and FISH requires a LIMS that can handle high throughputs and different workflows.

Why DORNER Genetics LIMS? - An expert view

Dr. Marie Bernkopf of the St. Anna Children's Cancer Research Institute emphasizes the flexibility of the DORNER Genetics LIMS as a key factor in her choice. The ability to combine different departments with different requirements in one system is invaluable to the institute. Particularly noteworthy are the worklist and batch processing functions, which enable efficient and digital handling of samples.

Familiarization with the system and user recommendation

The team at the St. Anna Children's Cancer Research Institute was able to familiarize itself with the DORNER Genetics LIMS relatively quickly. The daily routines were mastered within a few weeks, while the familiarization with new functions continues. Dr. Bernkopf recommends the system to other laboratories due to its adaptability and the ability to customize functions - a key advantage in the complex field of genetics.

Conclusion and outlook

The implementation of the DORNER Genetics LIMS at LabDia LaborDiagnostik and the St. Anna Children's Cancer Research Institute is an exemplary model for the integration of modern technologies into complex research and diagnostic processes. This development points the way to the future of laboratory diagnostics and underlines the importance of flexible, adaptable systems in science. It is proof of how innovative solutions can increase efficiency and contribute to improving the quality of research.

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The demand for genetic testing is experiencing a steady increase and remains critical in the medical landscape. With each innovation and new method, ever deeper insights into the genetic basis of health and disease are opened up. This development presents physicians with a wealth of opportunities, from treatment planning to diagnosis confirmation and therapy adjustment. But as the importance of genetic analysis increases, so does the challenge of handling a growing number of samples and requests.

In this development, highly specialized software solutions such as DORNER software have become an indispensable tool. These automate resource-intensive processes and significantly reduce the workload of medical staff. The DORNER Genetics LIMS has become indispensable at almost every workplace in genetics and has revolutionized the way laboratories work.

Bence Dvoràk, Laboratory Coordinator at the Oncology Laboratory of the University Children's Hospital Zurich, gave us an exclusive insight into the essential role of DORNER Genetics LIMS (Laboratory Information and Management System) in supporting their work.

Where does the DORNER Genetics LIMS become visible in your work in the laboratory?

Bence Dvoràk: From the documentation side, the DORNER Genetics LIMS comes into play in that we record everything both in paper form and electronically. This is done for both quality management and laboratory organization. We have been working with work lists for about a year and a half. Work lists and work batches are the two essential modules of the DORNER Genetics LIMS for us, and they are being introduced to us step by step. It is therefore necessary that we also record all data and information electronically.

Can you tell us more about the process of chromosome analysis and how the DORNER Genetics LIMS helps?

Bence Dvoràk: Both quality and quantity are recorded in the quality management system, i.e. the DORNER Genetics LIMS. Then the chromosomes are stained, and after staining they are placed on the Metafer G system from MetaSystems. This is a fully automated system that works with the help of artificial intelligence. It searches, finds, records and classifies the chromosomes. A good example of work simplification through automation. And thanks to the bidirectional connection to our [i/med] Genetics LIMS, karyotyping is started with one click and the results are fully imported.

How has the integration of the DORNER Genetics LIMS affected the efficiency of your work?

Bence Dvoràk: One example: as soon as we know that a chromosome analysis is being carried out, we press the 'Send metafer' button in the LIMS. This creates a patient folder on the server through which the two systems interact with each other. On the one hand, this is extremely practical for us, as we no longer have to enter all the individual data such as surname, first name and laboratory number manually, which is a potential source of error. Instead, we can simply rely on the systems and trust them. On the other hand, creating a karyogram can be time-consuming and tedious, and copying data back and forth between systems also carries the risk of errors. It is now set up so that once the karyogram is created in the Neon software, it is automatically transferred to the DORNER Genetics LIMS. The findings can then be completed there. In addition, we are obliged to archive a specific number of karyograms for each clone in digital form for 30 years, and this task is also facilitated by the DORNER Genetics LIMS.

Sounds like an impressive increase in efficiency. What about fluorescence in situ hybridization (FISH)? How does the DORNER Genetics LIMS support this process?

Bence Dvoràk: Again, all the steps are recorded in the DORNER Genetics LIMS, as all the work lists are mapped there to record which patients need to be examined and which probes are to be used. The approach here is in the laboratory, both manually and with the help of automated systems. However, quality assurance is ultimately performed again in the DORNER Genetics LIMS.

Can you also please tell us about next-generation sequencing (NGS) and region-specific comparative genomic hybridization (RSCGH)?

Bence Dvoràk: NGS and RSCGH are performed upstairs, but the principle is the same. All quality characteristics and all information about a patient are always recorded in the DORNER Genetics LIMS.

Video preview: Reference - [i/med] Sport at the Charité

The big advantage is actually the clarity. We really have a complete listing of all visits in the past for every single patient. From each visit, you can view all the examinations that have been performed. We can view the whole thing chronologically, but we can also sort it by content, which means it's very intuitively designed and very quick to call up and open.

Dr. Thomas Thouet, Institute of Sports Medicine at the Charité

At the Institute for Sports Science and Sports Medicine at the Charité in Berlin, our modular [i/med] Sport is used. A standard software solution that is also used or can be used in exercise and occupational medicine, training sciences and similar institutes.

We simply have this hybrid situation where, on the one hand, Charité as a whole is dependent on SAP. We have to use that. Clearly. At the same time, however, we naturally wanted to have a system in our microcosm, so to speak, that is as flexible as possible for us and where we can connect all our functional diagnostics. Where we also have our own design options. Both in terms of data input, but of course also in terms of data output and use of the data. And that's why we have our own "hospital information system" docked onto the SAP system. This allows us to more or less design the data management within the department ourselves.

Bernd Wolfarth from the Institute for Sports Medicine Charité

Prof. Dr. Bernd Wolfarth, Head of the Institute for Sports Medicine and Sports Science at the Charité, Berlin

An understandable concern, which we were able to realize with our [i/med] Sport: Starting with the extensive anamnesis required for sports medicine. Anyone who visits the sports medicine outpatient clinic at the Charité is given a tablet at the beginning of the examination on which the medical history is already recorded digitally. This data is automatically transferred to the digital patient file. There, they can not only be viewed by medical staff from anywhere, but the system also actively warns of any abnormalities:

For example, abnormalities in the family history. Sudden cardiac death below the age of 50 in the family history is an absolute warning signal and this is then also shown here again in a highlighted form, i.e. you can then also specifically address it again in the conversation and ask what actually happened.

Even before the interview, a number of different examinations take place. Usually starting with anthropometry, in which data such as height, weight, blood pressure, body fat, etc. are collected manually. For this purpose, there is a smart mask that automatically calculates the BMI, for example.
In order to simplify the work as much as possible and at the same time minimize the sources of error, the devices at the institute were connected to the [i/med] Sport. The order to the device is therefore carried out from the software and the results also end up there. Optionally as PDF partial results and/or as structured data. E.g. for a resting ECG. Or for an exercise ECG. And also for spirometry. It does not matter whether the device is connected directly via a bidirectional interface or has its own evaluation software to which the interface is implemented. And this even applies to data collected outside the institute.

This is a very comfortable matter. That means we can start the Merlin Viewer from [i/med], with which we have access in principle to all the image data of this person sitting in front of us, and we don't have to go back to SAP or somehow to the HIS or PACS. This is really, ultimately a fully integrated system with access to all data: Laboratory data, image data, examination data here from the institute, and just medical history data. That is very helpful.

Dr. Thomas Thouet

Call up and compare ultrasound images directly from [i/med] Sport

In other words, an all-in-all flexible, intuitive and, last but not least, modular system that provides users at the Institute of Sports Medicine at the Charité in Berlin with an end-to-end digitized, paperless workflow. From the eAnamnese, a waiting room overview module, to the individual functional diagnostics with the respective device and software connections, all the way to billing (private billing, collective billing for senders and, last but not least, KBV-certified health insurance billing). And finally, the almost completely automated physician letter writing, which saves an enormous amount of time.

As far as the creation of doctor's letters is concerned: We are faster with this and that is already something that will also be an important quality factor in the future. Because we have all the information digitally, we can easily share it with doctors, hospitals and other healthcare providers. This is important to ensure the best possible care. In the future, we will probably have a common electronic record for all patients, and we are already very well prepared for that.

Prof. Dr. Bernd Wolfarth

Collect all important information in one place and create a doctor's letter from it with one click

And as with all solutions based on our web-based DORNER Workflow Engine framework, you don't even have to be physically at the institute to use the system.

Ultimately, I have the option of logging directly into [i/med] via VPN from home using the browser, so that in principle everything that I would work on here at my desk can just as easily be done from home. Or sometimes, and that's what sports medicine is all about, that a test result has to be checked again at 8 or 9 a.m. on a Sunday because a competition or match might be coming up in the afternoon. Of course, it's also very elegant when you open the tunnel view (or VPN access) to the Charité and can view it in two mouse clicks from home.

Dr. Thomas Thouet

More information about [i/med] Sport

Learn more about our flexible IT solution for the Institute of Sports Medicine, Sports Science, Exercise and Occupational Medicine, the Training Sciences and at similar institutes .

Contact us today and convince yourself of the modular solution. Whether you are looking for a solution for the entire institute or want to digitize individual process steps (e.g. anamnesis or writing a doctor's letter)!

Brochure [i/med] Sport

Data protection enjoys a very high priority, especially for all medical data.

Video: i/med Billing - medical billing

More than 100,000 examinations per year billed with our DORNER Billing.

Workflow Engine Sports Medicine Charite

The Institute for Sports Medicine uses our i/med Sport in the entire outpatient workflow. One of many DORNER Workflow Engine solutions!

The Munich Leukaemia Laboratory is an international leader in leukaemia diagnostics. To make it as easy as possible for their senders to navigate through the complex spectrum of examinations, they used our DORNER Order Entry.

The Freiburg Medical Laboratory in Dubai has been our customer for almost 20 years and works 24/7 with our software.

SMS Lab Findings

Communication of findings in the fast lane. SMS to the patient directly with the medical report. Absolutely DSGVO-compliant through 2-factor authentication. All with DORNER [i/med] in just 4 weeks.

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